Ganoderma lucidum spore powder consists of reproductive cells released during the mature stage of the fungus and concentrates the core nutrients and bioactive components of Ganoderma lucidum. Recent advances in the field of wall-broken Ganoderma lucidum spore powder were systematically summarized, with a focus on four core directions: the permitted scope and identification techniques of Ganoderma strains for health foods, optimization of wall-breaking processes and quality control, safety evaluation, and functions and mechanisms. Combined with policy orientation and market demand, future development suggestions were proposed, including strengthening strain management at the source, establishing a full-chain quality system, deepening mechanism research, and expanding precise application scenarios.