Objective To explore the determination methods and migration patterns of 22 organophosphate flame retardants (OPFRs) in degradable food contact materials.Methods Samples were soaked in four kinds of food simulants. Ten percent ethanol and 3% acetic acid simulants were extracted with acetonitrile and salted out with NaCl. Olive oil was extracted with methanol/acetonitrile (v/v, 2/3), and 50% ethanol simulants were filtered and directly measured. OPFR extracts were separated by a C₁₈ column and determined by positive electrospray ionization (ESI+) in multiple reaction monitoring mode, with quantification by matrix external standard method. The migration pattern of triphenyl phosphate (TPhP) in simulants was analyzed and applied to determine migration of OPFRs in biodegradable food packaging bags and disposable gloves.Results The recoveries of 22 OPFRs ranged from 76.7% to 119.9%, with relative standard deviations of 0.23% to 11.30%. Limits of detection ranged from 0.06 to 1.14 μg/L, and limits of quantification ranged from 0.20 to 3.75 μg/L. Migration of TPhP from degradable food contact materials into 50% ethanol and olive oil increased with soaking time and temperature. Among 26 samples, the detection rate of OPFR migration was 76.9%, with only TPhP detected, migrating exclusively into 50% ethanol and olive oil.Conclusion Prolonged contact of degradable food packaging bags and disposable gloves with fatty foods or dairy products poses a safety risk due to OPFR migration into food.