Objective To establish a method for rapid detection of 59 kinds of drugs illegally added in alcoholic products by high performance liquid chromatography-triple quadrupole mass spectrometry.Methods After ultrasonic extraction of methanol-water (volume ratio 5∶5), the samples are determined by high performance liquid chromatography-triple quadrupole mass spectrometry and quantified by external standard method.Results The 59 tested drugs show a good linear relationship in the corresponding mass concentration range, with a correlation coefficient greater than 0.992. The limits of quantitation are 0.1 and 0.2 mg/kg respectively. Under three addition levels, the average recoveries of 59 drugs range from 86.7% to 119.9%, and the relative standard deviation of precision and repeatability for the method is below 13.7% (n=6).Conclusion The method, boasting simplicity, good repeatability, high efficiency, and accuracy, is suitable for the detection of illegal additives including aphrodisiac, anti-fatigue, antipyretic, analgesic, sedative, and diuretic drugs in alcoholic products.