Food-derived ACE inhibitory peptides can regulate blood pressure mildly and specifically by inhibiting the activity of ACE,which has attracted widespread attention and extensive research.Immobilization of ACE can overcome the shortcomings of traditional free ACE,significantly improve its stability,and give better reusability. This review summarized the immobilization of ACE and its use as an affinity separation medium for selective enrichment of food-borne ACEIP components,and prospects for its industrial application.