Objective： This study aimed to develop relevant health products with ginseng and semen ziziphi spinosae as raw materials. Methods: HPLC and UV spectrophotometer were used to study the chemical components of different compatibility ratios of ginseng and semen ziziphi spinosae. The antioxidant activity in vitro of ginseng and semen ziziphi spinosae with different compatibility ratios was analyzed by DPPH free radical, ABTS⁺free radical, hydroxyl free radical and superoxide anion free radical scavenging rate. Moreover, the grey relational degree method was used, and entropy weight method was used as the discrimination coefficient for statistical analysis, combined with the characteristics of comprehensive evaluation to optimize the compatibility ratio. Results: The correlation analysis showed that the antioxidant activity of ginseng-semen ziziphi spinosae and the content of total phenolic acid, Jujuboside A and spinosin were significantly correlated; and the chemical content determination results showed that the total phenolic acid, Jujuboside A and spinosin content of ginseng- semen ziziphi spinosae (1∶1) were higher than the other ratio. The results showed that its antioxidant activity was stronger than other ratios. Furthermore, the pharmacodynamic bases of its antioxidant activity were total phenolic acid, Jujuboside A, and spinosin. Conclusion: The optimal ratio of antioxidant activity of ginseng and semen ziziphi spinosae is m _ginseng∶m_{semen ziziphi spinosae} at 1∶1.