Objective: The method for determination of Al, Cr, Ni, Cu, Zn, As, Se, Cd, Sb, Pb in puffed food by inductively coupled plasma mass spectrometry（ICP-MS） was established. Methods: Samples were pretreated by microwave digestion technology and molecular ion interference was eliminated by octopole reaction system（ORS）. Results: All elements had a good linear relationship within the linear range, with correlation coefficient r>0.999. The precision and repeatability of RSD values were ranged from 2.8% to 4.5%. The recoveries of elements ranged from 100.8% to 114.4%. Conclusion: ICP-MS combined with microwave digestion is simple in operation, effective in reducing sample loss and good in accuracy. It can be applied to the detection of multiple elements in puffed food. SPSS was used to analyze the results of pre-packaged food and bulk food. The test showed no significant differences in metal content between the two samples.