Objective: In order to develop and utilize the resource utilization rate of cellulase producing strains. Methods: A Bacillus subtilis XWS-A with complete cellulase production system and high activity was used as the starting strain to make bacterial Fuqu. Box-Behnken response surface design was used to optimize the technology of Fuqu, and its enzyme production characteristics were explored. Results: The optimum conditions of Fuqu making were fixed inoculum amount of 7.5%, culture temperature of 46 ℃, water content of 46%, Under these conditions, Bacillus subtilis XWS-A was effectively proliferated, and the biomass reached （4.5±0.3）×10¹¹ CFU/g; Fuqu had three kinds of cellulase activities, and the best conditions for determination were endonuclease. The activity of endo-β-glucanase was （2 510±70） U/g. The activity of exo-β-glucanase was （15±2） U/g. The activity of β-glucosidase was （30±3） U/g. Conclusion: By making Fuqu, XWS-A can effectively proliferate and improve the enzyme production of the strain, and the Fuqu can maintain the enzyme activity of the strain. It provides an effective way for the efficient utilization of cellulase producing strains and the development and utilization of cellulose resources.