The cam mechanism of the carton handle sorting device is designed to realize the functions of picking up the handle, removing invalid handles and sorting the handle during the working process of the carton handle sorting device. According to the movement requirements of the push rod when the finishing device picks up and removes the handle, the mathematical model of the cam mechanism design is established to obtain the actual contour curve of the cam. The three-dimensional model of the cam mechanism was established through SolidWorks software. The ADAMS software was used to simulate and analyze the speed and displacement of the guide rod of the mechanism follower, which showed that the movement law of the cam follower could achieve the work requirements of removing the handle. The prototype test showed that the carton handle finishing device could normally complete the picking and removing actions of the handle. The handle removing device operated normally. The average handle of a single handle hanging rod was 20 and the average effective rejection rate of the removing device was 83.6%. The test results met the design goals.