An instant powder was prepared by using Lilium brow-nii as main raw materials, and huaishan, lotus seeds, barley and red dates as auxiliary materials. Based on the single factor test, the ratio of raw and auxiliary materials, fan frequency, inlet air temperature and peristaltic pump speed were used as influencing factors, product yield and dissolution rate were indicators, and a response surface method was used to optimize the boiling granulation process of Lilium brownii powder. The results showed that the optimal granulation process of response surface were: ratio of raw and auxiliary of 6∶1, the peristaltic pump speed of 5 r/min, the inlet air temperature of 70 ℃, and the fan frequency of 25 Hz. Under this technological condition, the product dissolution rate was (73.61±1.84)%,and the yield of Lilium brownii powder was (79.65±1.21)%, which were 36.96% and 28.38% higher than before granulation, respectively. The analysis of variance showed that there was a high degree of agreement between the predicted value of the model and the verification test result, indicating that the model was reliable.