Sixteen elements (K, Na, Ca, P, Mg, Fe, Cu, Mn, Zn, Al, Cr, Ni, As, Cd, Hg and Pb) in canned food paste for infant were determined by ICP-OES/ ICP-MS after microwave digestion. Under the optimized conditions, the calibration curves for 16 elements were wide and correlation coefficients were greater than 0.999 7. Twenty samples were determined by the proposed method and the spiked recoveries were in the range of 88.5%~106.0%, the relative standard deviations were 1.46%~8.18% while the RSD ranges from 1.8% to 7.1% (n=8). The method provides the basis for scientific evaluation of the nutritional value and food safety risk of the supplement mud.