An analytical method for the simultaneous determination of new and traditional "lean meat powder"（Clenbuterol, Salbutamol, Ractopamine, Terbutaline, Isoprophane, Chlorpheniramine, Simmatrol, Fenoterol and Olaquindox and its metabolites） in pork by ultra performance liquid chromatography-tandem mass spectrometry was established. Pork samples were extracted with 2% formic acid-acetonitrile solution. The extracts were purified by neutral alumina column. After being dried and concentrated by nitrogen, the hexane was degreased and determined by ultra performance liquid chromatography-tandem mass spectrometry and quantified by internal standard method. Waters HSS C₁₈ column (100 mm×2.1 mm, particle size 1.8 μm) was used. The mobile phase was separated by acetonitrile and 0.1% formic acid aqueous solution. The electrospray ionization mode was used to determine the multi-reaction monitoring mode. The test can be completed in 7 minutes. The results showed that there was a good linear relationship between the compounds in the range of 0.2～20 μg/L, and the correlation coefficient was greater than 0.996 2. The detection limits and quantitation limits of fenoterol, ractopamine and clorprenaline were 0.1 μg/kg and 0.3 μg/kg; the detection limits and quantitation limits of clenbuterol were 0.05 μg/kg and 0.2 μg/kg, the detection limits and limit of quantitation of other compounds were 0.2 μg/kg and 0.5 μg/kg. At the three levels of addition (detection limit, 2 times limit of detection, 10 times limit of detection), the recovery of each target compound was 89.1% to 121.5%, and the relative standard deviation was 2.6% to 12.9% (n=6). The method is rapid, accurate and sensitive, and is suitable for the determination and confirmation of traditional and new " lean meat powder " residues in animal-derived foods such as pork.