Globoidal indexing cam mechanism is one of indexing mechanism with excellent performance.It has the advantages of high speed，large stiffness and strong bearing capacity. In this paper, based on the three-dimensional model of globoidal cam mechanism established by bi-cubic B-spline surface algorithm, a rigid-flexible coupling dynamic model is established with ADAMS software, and its kinematics analysis is carried out to verify the correctness of the model. Meanwhile，the mechanism is simulated and analyzed under different motion parameters, and the curves of angular acceleration and contact force under different parameters are obtained. The analysis of the curve of angular acceleration and contact force shows that the rotational speed and damping coefficient have influence on the dynamic characteristics of globoidal indexing cam. Especially during the grading period, the impact is most obvious. With the increase of the rotational speed of globoidal indexing cam, the angular speed and contact force of indexing-plate increase gradually. With the increase of the damping coefficient, the maximum angular acceleration of the indexing plate will decrease first（minimum at 150 N·s/mm） and then increase, while the contact force between the roller and the indexing plate will increase with the increase of the damping coefficient