This paper is aimed at studying the relationship between the safflower seeds with different linoleic acid content and its sprouts quality, to provide reference for the scientific production of safflower sprouts. The yield and quality of the safflower sprouts from 8 varieties (lines) with different linoleic acid content were analyzed and compared. The results showed linoleic acid content of PI305192 in seeds was the highest.The hypocotyl length and edible fresh weight of PI305192 sprouts were the highest, its edible fresh weight was significantly higher than that of other varieties (lines) except for PI544040.The contents of linoleic acid of Chuanhong No. 1 and PI198294 was significantly lower than that of PI305192, but significantly higher than that of PI401479 and PI470942. Among them, the content of soluble protein in Chuanhong No. 1 sprouts was the highest, but there was no significant difference compared with PI305192 and PI198294.The contents of free amino acid and soluble sugar of PI198294 and Chuanhong No.1 was significantly higher than the other varieties (lines). The total polyphenol content in Chuanhong No.1, PI198294 and PI544040 were higher compared to other varieties (lines). The total flavonoid content in Chuanhong No.1 was high; while the content of total flavonoids in PI198294 was not low . Therefore, Chuanhong No 1 and PI198294 sprouts had a better quality. It was also found that the content of linoleic acid in safflower seeds was significantly positively related to edible fresh weight, edible dry weight and soluble protein content of sprouts, while the oleic acid content in safflower seeds showed significant negative correlation above indexes. Overall, yield and quality of safflower varieties (lines) which had higher oleic acid content was relatively better. The results of this study can be used to guide the production of safflower sprouts.