In this study, six different macroporous adsorption resins were evaluated for their use to purify lignans ethanol-extraction of camphor tree leaves，a suitable macroporous adsorption resin was selected as the purification material. The effects were investigated, such as sample concentration, flow rate, volume of sample on adsorption rate of macroporous resin, and the effects of concentration, flow rate and dosage of eluent on desorption rate of the macroporous resin were also studied . The optimal purification process of lignan with the macroporous resin was studied by the orthogonal experiment. The purication parameters optimized by adsorption and desorption were determined as follows: sample loading amount 7 BV, sample concentration 2.12 mg/mL, ow rate 1.0 mL/min, dosage of desorption ethanol solvent 80%, ow rate 2 BV/h, eluent volume 8 BV. Under the optimized conditions, the yield and purify of lignans were 66.68% and 15.91%, respectively, which indicated that the macroporous resin has better purification effect on lignans in camphor leaves.