To further improve the performance of non-enzymatic electrochemical glucose sensor, a one-step in-situ oxidation method was used to prepare nickel oxide material directly grown on nickel foam. Moreover, the indium and tin ions were doped into the nickel oxide material during the growth process, and an In-Sn@NiO composite could be obtained. XPS measurement indicated that the indium and tin ions were successfully doped into nickel oxide material. Through the SEM images, the surface of the doped nickel oxide electrode showed a structure of nanorods instead of nanosheets. Compared with undoped material, the structures could benefit the transport of surface particles. From the results of electrochemical sensitivity test towards glucose, this electrode exhibited a remarkable performance with a sensitivity of 91.9 mA/(μmol·L^-1·cm²) and the limit of detection was 0.02 μmol/L.