After 5 weeks feeding, the type 2 diabetes mellitus was established by intraperitoneal injection of low-dose STZ (75 mg/kg), to measure and statistically analyz the body weight, blood lipid level, fastig blood glucose level. The extracs of Oenanthe javanica can prevent the increase of blood glucose and the reduction of blood weight in STZ-induced type 2 diabets mice. In the study, the type 2 diabetic mice modle using high glucose and high fat diet and low dose STZ injection occurred at 3weeks, the achievment ratio was 80%, the aqueous extracts composition mold rate was 40%, the alcohol extracts was 60%. Therefore, Oenanthes Javanicae extracts on high glucose and high-fat diet induced STZ mice with type 2 diabetes mellitus model has certain intervention effect.