To explore the solvent extraction to reduce cigarette harm and tar, the optimal extraction conditions of tobacco, according to the change of release amount of HCN and ammonia treated tobacco pyrolysis simulation, were determined by optimizing the conditions such as extraction solvent, broken wall, and extraction times. Additionally, reduction mechanism of the solvent extraction on the reduction of hydrogen cyanide and ammonia was discussed. Tobacoo treated with optimal extraction conditions could significantly reduce the release of HCN and ammonia in tobacco because of the solvent extraction to extract the precursor of HCN and ammonia content in tobacco. The results showed that moisture retention ability of tobacco was almost unchanged, and the tar, CO, benzopyrene and phenol of tobacco were also decreased, whereas the degree of softness, aftertaste and irritant were improved. The study could provide new ideas and methods for cigarette industry enterprises to reduce the harm and tar and use the low-grade tobacco.