Rice with cadmium content of 0.977 8 mg/kg was studied as the main material, its cadmium removal rate was regard as the basic measuring index. The process parameters of reducing techniques for cadmium-tainted rice were optimized by single factor test and Box-behnken response surface design. The investigation were focused on the effects of temperature, time, mesh number of rice, solid-liquid ratio, and inoculation amount. The optimal parameters were found as follows: mesh number of rice 40, inoculation amount 3, solid-liquid ratio 15, treated at 37 ℃ for 21 h. Under this optimum conditions, the cadmium removal rate was 89.98%, which was similar to the predicted value of 89.736 2%.