The effects of cigarette machine operating parameters were studied on the yield of different grades of cigarettes. The effects of operating parameters, such as the amount of running silk, yarn feeding and yarn supply and the volume of ticking, on the yield of cigarettes A, B and C were studied by uniform design method. The results were as follows. ① The polynomial models of the running parameters and yield of different grades cigarettes were established. for A grades, it was Y_A=27.500+0.704X₂+1.72E-03X^2.08₁-2.110E-03X₁X₃; for B grades, it was Y_B= 98.250 +8.29E-03X₃-1.170E-03X₂X₄; and for C grades, it was Y_C=72.991+1.262X₄+7.550E-05X₂X₃. R² were 0.990, 0.994, and 0.999 respectively, and they showed good descriptions of the relationship between the operating parameters and the yield. ② Optimization of operating parameters was found to be increasing the total amount of wire and adjusting appropriately the secondary air damper opening. It was confirmed by practical producing that the optimized yield was enhanced, and the yield was increased by 2.6%. Finally, a certain optimization effect on improving the yield was obtained.