To study the structure and property, the interaction between the material and the food simulant under High Pressure Processing (HPP). Two kinds of plastic films including PA/PE and PET/PE which have the contents of soy protein, fats and other food were processed under ultra-high pressure condition, stored a certain period and measured the interaction between the food contents and packaging materials under different pressure and dwell time. The results show that: the performance of high pressure treatment of two polymer packaging materials is better than the packaging materials which are not to be treated in a certain storage period; Holding time under certain circumstances, increasing the pressure is good to the shelf life of food contents, the higher the pressure, the more obvious the effect; Pressure under certain conditions, holding time does not produced regularity impact on the food contents and packaging materials. Pressure and storage of period can produce influence on the food simulant and material.