基于动态血糖监测技术的糖缓释主食餐后血糖波动特性研究
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1.湖南农业大学园艺学院,湖南 长沙 410128;2.国家中医药管理局亚健康干预技术实验室,湖南 长沙 410128;3.长沙能峰生物科技有限公司,湖南 长沙 410128

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刘东波(1970—),男,湖南农业大学教授,博士。E-mail:chinasaga@163.com

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国家自然科学基金项目(编号:81773850)


Characterization of postprandial blood glucose fluctuations following consumption of slow-release carbohydrate staple foods by continuous glucose monitoring
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1.College of Horticulture, Hunan Agricultural University, Changsha, Hunan 410128, China;2.State Key Laboratory of Subhealth Intervention Technology, Changsha, Hunan 410128, China;3.Changsha Nengfeng Biotechnology Co., Ltd., Changsha, Hunan 410128, China

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    摘要:

    目的 探究动态血糖监测系统(continuous glucose monitoring system,CGMS)对进食糖缓释主食餐后血糖波动的影响及特点。方法 共纳入8名健康成年受试者,进行为期15 d的连续血糖监测(continuous glucose monitoring,CGM)并采集餐后静脉血样以观察血糖波动情况。试验期间,受试者在第2天和第14天早晨空腹分别摄入葡萄糖水(对照食物),第5、8、11天早晨空腹分别摄入糖缓释主食、普通大米和低GI高抗性淀粉大米,持续监测餐后4 h动态血糖变化及测定静脉血血糖值。监测指标包括葡萄糖目标范围内时间(time in range within 4 h postprandial,TIR4h)、血糖恢复至空腹水平时长(time to return to fasting blood glucose levels within 4 h postprandial,Tb4h)、血糖生成指数(4-h postprandial glycemic index,GI4h)及食物血糖负荷(4-h postprandial glycemic load,GL4h)。结果 在5次食物测试中,葡萄糖水平均TIR4h为85.6%,而糖缓释主食的餐后TIR4h达到了100%,显著高于葡萄糖水(P<0.05)且优于其他2种食物。葡萄糖水的平均Tb4h值为112 min,糖缓释主食为167 min,显著高于葡萄糖水(P<0.05)。动态血糖监测3种受试食物GL4h结果分别为55,60,47,普通大米与糖缓释主食GL4h值高于低GI高抗性淀粉大米,静脉血血糖监测3种受试食物GL4h结果分别为52,64,40,普通大米与糖缓释主食GL4h值显著高于低GI高抗性淀粉大米(P<0.05)。基于以上结果,糖缓释主食的TIR4h值为100%,显著高于葡萄糖水且优于其他2种食物,Tb4h值为167 min显著高于葡萄糖水,GL4h值显著高于低GI抗性淀粉大米。结论 糖缓释主食能够显著降低人体餐后血糖波动幅度,同时保证足够的能量供应。

    Abstract:

    Objective To investigate the effects and characteristics of the continuous glucose monitoring system (CGMS) on postprandial blood glucose fluctuations following the consumption of slow-release carbohydrate staple foods.Methods This study enrolls eight healthy adult participants for 15-day continuous glucose monitoring (CGM) and collects postprandial venous blood samples to observe blood glucose fluctuations. During the trial, participants consume control food (glucose solution) in the morning on days 2 and 14 after fasting and slow-release carbohydrate staple foods, regular rice, and low-GI high-resistant starch rice on days 5, 8, and 11, respectively. Postprandial 4 h blood glucose changes and venous blood glucose levels are monitored. Key metrics include time in range within 4 h postprandial (TIR4h), time to return to fasting blood glucose levels within 4 h postprandial (Tb4h), 4 h postprandial glycemic index (GI4h), and 4 h postprandial glycemic load (GL4h).Results Among the five food tests, the control food (glucose solution) shows the TIR4h of 85.6%, while the slow-release carbohydrate staple foods achieves the TIR4h of 100%, which is higher than that of glucose solution (P<0.05) and superior to the other two food types. The average Tb4h of the glucose solution is 112 min, whereas that of the slow-release carbohydrate staple foods is 167 min, longer than the control (P<0.05). CGMS-derived GL4h values for the three test foods are 55, 60, and 47, with regular rice and slow-release carbohydrate staple foods showing higher GL4h than low-GI high-resistant starch rice. Venous blood measurements yield GL4h values of 52, 64, and 40, with regular rice and slow-release carbohydrate staple foods showing higher GL4h than low-GI high-resistant starch rice (P<0.05). These findings indicate that the slow-release carbohydrate staple foods exhibit higher TIR4h (100%), Tb4h (167 min), and GL4h than low-GI high-resistant starch rice.Conclusion Slow-release carbohydrate staple foods significantly attenuate postprandial blood glucose fluctuations while achieving sustained energy provision in the human body.

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李凯,王世龙,朱令,等.基于动态血糖监测技术的糖缓释主食餐后血糖波动特性研究[J].食品与机械,2025,41(6):144-149.
LI Kai, WANG Shilong, ZHU Ling, et al. Characterization of postprandial blood glucose fluctuations following consumption of slow-release carbohydrate staple foods by continuous glucose monitoring[J]. Food & Machinery,2025,41(6):144-149.

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  • 收稿日期:2025-01-25
  • 最后修改日期:2025-05-20
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  • 在线发布日期: 2025-07-04
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