Objective To analyze the effects of migration temperature, heating time, and copper content on the migration of copper from regreen Indocalamus leaves to food simulants.Methods Regreen Indocalamus leaves were prepared by being soaked in copper sulfate pentahydrate solutions. Food simulants included ultrapure water, 2.5% (mass fraction) sodium chloride solution, 4% (volume fraction) acetic acid solution, 10% (mass fraction) white sugar solution, soybean oil, and 5‰ (mass fraction) sodium bicarbonate solution. The effects of migration temperature, heating time, and copper content on the migration amount of copper from regreen Indocalamus leaves were analyzed.Results Except for soybean oil, the migration amount of copper from regreen Indocalamus leaves was the largest in 4% acetic acid solution, followed by 2.5% sodium chloride solution. When the migration temperature was 100 ℃, the copper migration amount in all food simulants reached peaks in 2 hours, and then decreased as time elapsed; when the migration time was 24 hours, the migration amount reached peaks in ultrapure water, 2.5% sodium chloride solution and soybean oil at 40 ℃, and the migration amount reached peaks in 4% acetic acid solution and 10% white sugar solution at 25 ℃; The higher the copper content of regreen Indocalamus leaves is, the greater the migration amount is.Conclusion The properties of food simulants, heating time, and temperature are important factors affecting the copper migration from regreen Indocalamus leaves. As the copper content of regreen Indocalamus leaves is higher, the migration amount is greater, and acidic food is more conducive to copper migration.