［Objective］ This study aimed to determine the optimal processing conditions for Dali ginseng (DG) and evaluate its antioxidant activity.［Methods］ Total ginsenosides content in DG was measured under different liquid -material ratios,temperatures,and extraction time.The response surface method was employed to optimize the processing conditions.UPLC -QQQ -MS was used to analyze the ginsenoside content,and the antioxidant activity of DG extracts with different polarities was evaluated using various antioxidant indexes.［Results］］ The optimal processing conditions of DG were processing at 95 ℃ with liquid -solid ratio 22∶1 (mL/g ) for 30 mins.Under the control of these conditions,the maximum content of total ginsenosides at 3.75% was achieved.All the DG extracts certain antioxidant activity,among which the ethyl acetate extract has the strongest antioxidant activity.［Conclusion］ The optimum processing technology and antioxidant active parts of Dali ginseng were obtained.