氧化玉米淀粉/明胶复合胶囊壳的制备与表征
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(1. 长沙理工大学化学化工学院,湖南 长沙 410076;2. 湖南工业职业技术学院机械工程学院,湖南 长沙 410000;3. 岳阳天添胶囊股份有限公司,湖南 岳阳 414000)

作者简介:

谭心,女,长沙理工大学在读本科生。

通讯作者:

陈启杰(1980—),男,长沙理工大学教授,博士。E-mail:chenqijie@126.com

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国家级大学生创新训练计划项目(编号:S202310536039)


Preparation and characterization of oxidized corn starch/gelatin composite capsules
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(1. School of Chemistry and Chemical Engineering, Changsha University of Science & Technology, Changsha, Hunan 410076, China; 2. College of Mechanical Engineering, Hunan Industry Polytechnic, Changsha, Hunan 410000, China; 3. Yueyang Tiantian Capsule Co., Ltd., Yueyang, Hunan 414000, China)

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    摘要:

    目的:采用改性淀粉与明胶共混制备胶囊壳,降低胶囊壳制备成本。方法:以玉米原淀粉为原料,采用15%用量的过氧化氢氧化制备氧化玉米淀粉,与明胶共混,分别通过流延法和浸渍法制备了氧化玉米淀粉/明胶复合胶囊膜和胶囊壳,并采用傅里叶变换红外光谱(FT-IR)、X射线衍射(XRD)、扫描电子显微镜(SEM)对其进行表征。结果:当氧化玉米淀粉与明胶质量比为5∶5,制备的氧化玉米淀粉/明胶复合胶囊壳的干燥失重在13.0%~15.0%,在蒸馏水和模拟人工胃液中的崩解时限在10 min以内,脆碎度不超过5粒。结论:采用氧化玉米淀粉与明胶共混制备的复合胶囊壳性能符合《中国药典》(2020)要求。

    Abstract:

    Objective: Modified starch was used to mix with gelatin to prepare the capsule shell, and the cost of preparing the capsule shell was reduced. Methods: Oxidized corn starch prepared by using 15% hydrogen peroxide was used as raw material to mix with part of gelatin. The oxidized corn starch/gelatin composite film and capsules were prepared by casting method and impregnation method, respectively, and were characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and Scanning electron microscopy (SEM). Results: The results showed that the ratio of oxidized corn starch and gelatin was 5∶5, the drying weight loss of oxidized corn starch/gelatin composite capsules was 13.0%~15.0%, the disintegration time in distilled water and simulated artificial gastric juice was less than 10min, and the crunchability was not more than 5 granules. Conclusion: The properties of the composite capsule prepared by blending oxidized corn starch with gelatin met the requirements of Chinese Pharmacopoeia (2020).

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谭 心,梁春艳,邓松林,等.氧化玉米淀粉/明胶复合胶囊壳的制备与表征[J].食品与机械,2024,40(5):188-193.
TAN Xin, LIANG Chunyan, DENG Songlin, et al. Preparation and characterization of oxidized corn starch/gelatin composite capsules[J]. Food & Machinery,2024,40(5):188-193.

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  • 收稿日期:2024-03-04
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  • 在线发布日期: 2024-07-22
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