Objective: This study aimed to explore the best irradiation method and irradiation dose to treat Choerospondias axillaris pastilles. Methods: C. axillaris pastilles were irradiated with 0～10 kGy gradient dose of ⁶⁰Co-γ ray and electron beam respectively, the changes of the indexes including microbial load, protein, fat, total sugar, L(+)-ascorbic acid, organic acids, pH value, sensory quality, and the shelf life quality stored in 0～360 days at room temperature were studied. Results: ⁶⁰Co-γ ray and electron beam irradiation both had bactericidal effects on C. axillaris pastilles, all microbial limit indexes including aerobic bacterial count, coliform bacteria, mold, and the pathogenic bacteria limit indexes including salmonella and staphylococcus aureus were not detected in the samples with the irradiation dose of 4 kGy. The contents of protein, fat, total sugar, organic acids (mainly citric acid), pH, and sensory quality in C. axillaris pastilles were not significantly affected by ⁶⁰Co-γ ray and electron beam irradiation of less than 10 kGy. However, the content of L(+)-ascorbic acid was significantly decreased compared with the control group after irradiation (P＜0.05), it was negatively correlated with irradiation dose, and ⁶⁰Co-γ ray irradiation had a greater impact than that of electron beam irradiation. The C. axillaris pastilles batch products were irradiated with ⁶⁰Co-γ ray and electron beam of 4～10 kGy, the products were stored for 0～360 days at room temperature, and the microbial limit indexes including aerobic bacterial count, coliform bacteria, mold in the products were less than 10 CFU/g. There were no significant changes in the smell, taste, and tissue state of C. axillaris pastilles, but with the extension of storage time, its color deepened due to browning, but it was still acceptable within 270 days of storage. Conclusion: ⁶⁰Co-γ ray and electron beam irradiation both are effective methods for sterilization and storage of C. axillaris pastilles, and the recommended irradiation dose is 4～10 kGy.