Objective: To solve the problem that the thickness and tightness of the rhizopus brick by traditional mechanical stamping JIUQU starter press were different, so as to achieve the effect of manual trampling on the liquor. Methods: Through the analysis of the existing JIUQU starter press machine in the distillery, the transmission mechanism of the mechanical stamping JIUQU starter press machine was optimized, the original crank connecting rod mechanism that controlled the movement of the JIUQU starter die was replaced by the groove cam mechanism, and the cam profile curve was inversely calculated according to the relationship between the JIUQU starter press force and the compression amount of the JIUQU starter press material, and the eleventh degree polynomial cam profile curve that conforms to the compression deformation of the JIUQU starter press material was constructed. Results: Compared with the original mechanism, it can reduce the movement time of non working stage by 75.09% and increase the movement time of working stage by 192.60%. Conclusion: After the optimization design, the JIUQU starter press force is matched with the compression amount of JIUQU starter and the effect of the optimal of best JIUQU starter press is achieved.