Objective: In this study, the finite element simulation was integrated into random vibration experiment to provide a new way of thinking about transportation packaging. Methods: The red wine inner packaging spacer, made of three different cushioning materials, was used as the research object, and the vibration response was studied through random vibration experiment. Then the finite element simulation was used to analyze the correlation between the experiment and the simulation results. Results: The results of random vibration test were highly consistent with the results of finite element simulation, and the finite element simulation was less material- and time-consuming, compared with the random test. Conclusion: The combination of random experiment and finite element method can improve the efficiency of the experiment. The finite element simulation method can provide effective guidance for the analysis and design of product inner packaging under the vibration environment of transportation.