Objective: To improve the separation efficiency of constricted clam shell and meat. Methods: Taking Lianyungang double-headed razor as the test object, taking frequency, amplitude, and sieve surface inclination as the test factors, and taking the screening efficiency and the ratio of the shell in the meat as the main control targets, a single-factor test was carried out, and the test results were analyzed by Design-Expert software. An analysis of variance was performed to establish a regression model matching the frequency, amplitude, and inclination of the screen surface to the screening efficiency and the ratio of husks in the meat. Using the response surface optimization analysis method, the optimal matching of working parameters for the separation and screening device of constricted razor shell and meat was obtained. Results: When the discharge rate was controlled at 1.2 kg/s, the shell opening rate was controlled at 97%, the frequency was set at 21.6 Hz, the amplitude was set at 3.6 mm, and the screen inclination angle was set at 9°, the screening efficiency of constricted razor was improved, with the screen efficiency of 97.60%, and the shell-on ratio of the meat of 4.52%. Conclusion: The designed vibrating screening device for constricted razor has high screening efficiency and good adaptability, which can meet the preliminary processing requirements.