Holistic governance theory is a new type of public management strategy, which helps to provide citizens with a seamless and non-separated holistic service governance scheme, and provides new ideas for food safety supervision. Based on the theory of holistic governance, this article proposes three levels of online food safety supervision, from the perspective of the integrity of supervision implementation to reconstruct the execution network, the integrity of the supervision body to reconfigure of the participating network, the integrity of the supervision accountability to reshape of the power and responsibility system.