Objective:This study aimed to reveal the composition differences and antioxidant activities of kernel and peel from raw and fried semen from Ziziphi spinosae.Methods:Using 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical, hydroxyl radical (·OH), superoxide anion radical (O-2·), 2,2'-amino-di (3-ethyl-benzothiazoline-6-sulphonic acid) ammonium salt (ABTS) free radical scavenging ability and ferric reducing antioxidant power (FRAP) to determine the antioxidant activity of peel, kernel and jujube benevolence from different semen. Moreover, the components of peel, kernel and jujube benevolence were also studied by UV spectrophotometer.Results:The results showed that the peel, kernel, and jujube benevolence of all the semen had certain antioxidant effects, and the order of their antioxidant capacity was peel＞ jujube benevolence＞ kernel. The composition study showed that the contents of total flavonoids, total saponins and total phenolic acids in the semen peel were higher than those in jujube benevolence and kernel, and there was no significant difference in the content of total polysaccharides among samples. Therefore, the pharmacodynamic material basis of antioxidant activity in the peel was verified to be flavonoids, saponins and phenolic acids. However, there was no significant difference in antioxidant activity, total saponins, total flavonoids, total phenolic acids and total polysaccharides between the raw and fried semen.Conclusion:The peel, kernel and jujube benevolence of raw and fried Ziziphi spinosae semen all have antioxidant activity, and this provides a theoretical basis for the further development and market application of Z. spinosae semen.