Objective:An occlusion simulation device based on multi-link structure was developed for occlusion simulation test.Methods: The feasibility of using multi-link structure to reconstruct human oral occlusal trajectory was analyzed. Based on the multi-link structure, the mechanism of the occlusal simulation device was designed. Solidworks software was used to simulate the movement trajectory of the device, and the effectiveness of the occlusion simulation device was verified by experiments.Results:The maximum opening distance of the occlusion simulation device was 50 mm. The maximum bite force of carrot was 65.77 N, and the minimum was 2.05 N of tofu. The results of occlusion simulation test were positively correlated with those of sensory evaluation test, which verified the effectiveness of occlusion simulation device.Conclusion:The occlusion simulation device could effectively simulate the bite in vitro, and its force measurement results could be used to study food texture.