Objective: This study aimed to optimization of polysaccharide extraction process from Aralia elata (Miq.) Seem by complex enzymes and research of its antioxidant activity. Methods: The cellulase, pectinase and papain were combined as the compound enzymes and used to extract the polysaccharide from A. elata (AEPS). Enzymolysis temperature, enzymolysis duration, and solid-liquid ratio as the independent variables, a three-level-three-factor scheme was designed using the Box-Behnken method. After that, the antioxidant activity of AEPS was determined by the free radical scavenging ability experiments. Results: The optimal process conditions for the extraction process of AEPS using complex enzymes were as follows: enzymolysis at 54 ℃ for 160 min, with a ratio of solid-liquid 1∶31 (g/mL). Under the control of these conditions, the average AEPS extraction rate was (10.68±0.05)%, closing to 10.78% predicted by the model. According to the DPPH assay, the half-maximal inhibitory concentrations (IC₅₀) of AEPS concerning the free radicals and hydroxyl radicals were 2.00 mg/mL and 3.05 mg/mL, respectively. With the increasing polysaccharide concentration, the scavenging rate increased, with the maximum scavenging of 78.10% and 70.10%. Conclusion: The extraction rate of polysaccharides of Aralia elata was improved by the compound enzyme method, and AEPS had higher antioxidant activity.