Objective： To evaluate the hypoglycemic effect of compound almond powder on glucose and lipid metabolism disorder rats. Methods: High-fat diet and dexamethasone were used to establish an insulin resistance rat model of glucose and lipid metabolism disorder. Regular diet was used as a negative control, and metformin was used as a positive control. Fasting blood glucose, serum insulin, blood glucose and area under blood glucose curve after half an hour of glucose loading were measured, and blood lipid data were measured. Results: the fasting blood glucose of normal rats was not affected by compound almond powder (P＞0.05); After successful modeling, the fasting blood glucose of rats with insulin resistance and glucose and lipid metabolism disorder did not show significant fluctuations, while the half-hour blood glucose level and area under the blood glucose curve after glucose load showed a significant downward trend, with the blood lipid index and insulin resistance index not showing significant changes. Conclusion: Compound almond powder has no effect on blood glucose of normal rats but has a positive effect on glucose tolerance index of glucose and lipid metabolism disorder rats. However, no significant increase was found in blood lipid. The hypoglycemic effect of compound almond powder was confirmed.