Objective: The aim of this work is to improve the food safety of rewetting-dried shiitake mushrooms. Methods: The drum catalytic infrared device was used to carry out the infrared combined holding treatment disinfection test on rewetting-dried shiitake mushrooms with excessive Aspergillus niger （A. niger）, and the effect of process parameters on disinfection effectiveness, drying effectiveness and quality of mushrooms were investigated. Moreover, the kinetics of the microbial inactivation process was analyzed. Results: The results showed that after disinfected with DCIR at 60～80 ℃ for 8.7～21.2 min，followed by holding for 20～80 min, the total number of moulds on mushrooms with IMCs of 16.0%～21.4% was less than 2 lg(CFU/g), which could meet the national food hygiene standard. The Log-Linear plus Tail model fitted well the inactivation regularity of A. niger during the holding process （R²＞0.98）. Meanuhile, moisture （w.b.） of 2.2%～6.0% was removed from the mushrooms to achieve simultaneous drying. Considering the disinfection time and product quality indicators, it was recommended that mushrooms treated with DCIR for 10.8～15.2 min to 70 ℃ （the feed rate of DCIR was 38～50 kg/h）, followed by holding at 70 ℃ for 30～60 min as the most suitable disinfecting process condition. Under the control of this process condition, the high-quality product was obtained. Conclusion: Drum catalytic infrared radiation combined with holding treatment was a promising disinfection technology during rewetting-dried shiitake mushrooms disinfecting.