Objective: To study the hypoglycemic effect of dandelion extract on type 2 diabetes (T2DM) rats. Methods: High-fat and high-sugar feed and streptozotocin (STZ) were used to establish type 2 diabetic rat model. The blank normal group, model group, dandelion high-dose group (400 mg/kg) and dandelion low-dose group (200 mg/kg) were set up in the experiment, positive group (150 mg/kg). Fasting blood glucose (FBG), glucose tolerance level (OGTT), insulin resistance (FINS) and insulin sensitivity (HOMA-IR) were measured in T2DM rats, and TC, TG, ALT, AST, SOD, GSH, CAT, MDA related indicators were measured. Results: Compared with the model group, the FBG, FINS and HOMA-IR of T2DM rats treated with dandelion extract were significantly reduced (P＜0.05), and the levels of TC, TG, ALT and AST were also significantly reduced (P＜0.01), SOD, GSH, CAT increased significantly (P＜0.01), MDA significantly decreased (P＜0.01). Conclusion: Dandelion extract can improve insulin resistance, increase the antioxidant leveland improve lipid metabolism in T2DM rats, thereby exerting a hypoglycemic efficacy.