In order to improve the quality of products in the fermentation process and increase the output of products and optimize the fermentation process. a set of fermentation process measurement and control system based on SIEMENS PCS7 and Batch formulation system was designed in this study. Moreover, the centralized management of data was realized through MES system and report system. The system consisted of network part, hardware part, software part and data processing part. The double redundant ring network structure was adopted in the network part. The CPU400 redundant structure was adopted in the hardware part. PCS7 and batch were used in the software design. MES and report system were used for data processing. All parts formed the whole fermentation measurement and control system from bottom to top, which realized the process control of industrial fermentation.