In order to ensure the quality and safety of plant solid beverages, and increase the basis for export, a new experimental method was built for the determination of ten phytotoxins, including protostemonine, thujone, coumarin, berberine hydrochloride, safrole, santonin, aloin, asarone, isosafrole, pulegone in solid beverage by High Performance Liquid Chromatography(HPLC). The samples were extracted with acetonitrile, purified with QuEChERS, then them were separated by gradient elution in Wlech Xtimate C₈ column (4.6 mm×250 mm, 5 μm) and detected by PDA detector, with methanlo-ammonium acetate (10 mmol/L, pH 3.5). The results indicated good linear relationships in the range of 0.005~154.200 mg/L for the ten phytotoxins, with correlation coefficient greater than 0.997. The limits of detection (LODs, S/N=3) and quantification (LODs, S/N=10) of the method for the target compounds were in the range of 0.010~0.270 mg/kg and 0.032~0.830 mg/kg, respectively. The mean recoveries of negative samples at three spiked levels were between 78.46% and 100.77%, and the relative standard deviation (RSD, n=6) 1.10%~3.07%, the daily precision were 1.11%~2.73%. This method was suitable for the identification and quantification of ten phytotoxins in botanical solid beverage owing to its simplicity and accuracy.