The ability of sports drinks for enamel corrosion was measured and evaluated in this study. A single-center-single-blind-random crossover design was performed to balance the residual effects of the 18 test results. The beverages used included beverages containing calcium and maltodextrin (test group), two kinds of sugar-containing sports drink products (containing calcium and positive control) and water (negative control). During the 15-day study period, subjects wore removable human enamel simulation samples and drank 250 mL of beverages 4 times a day. The loss of tooth enamel was measured using contact profilometers on days 5, 10 and 15. On the 15th day, a difference was found between the test groups and the negative control. The positive control gradually eroded, and the degree of enamel corrosion was greater than that of the test group and the negative control, as the treatment lasted longer. The results showed that calcium and pH adjusters might be added to soft drinks, carbonated drinks, and sports drinks, to reduce the long-term corrosion of teeth by drinking drinks.