Investigated effects of vitamin B complex TRP peptides and SOD on the anti-oxidative activity in brain tissue, serum inflammatory factor levels and reverse anxious/depression-like behaviors. Vitamin B complex TRP peptide and SOD (V_B3︰ V_B6︰TRP peptide︰SOD = 2︰10︰3︰4; VBPS) high, medium and low gavage doses were 260, 195, 130 mg/(kg·d), respectively. Studies showed that VBPS could reverse the anxious/depression-like behaviors and the slow body weight gain, with VBPS at a high dose being more effective. VBPS showed to control the effects of serum inflammatory cytokines (TNF-α, IL-6, IL-1β and IFN-γ), decrease malondialdehyde (MDA) levels and increase superoxide dismutase (SOD), catalase (CAT), nitric oxide synthase (NOS) activity. In addition, VBPS induced down-regulation of TRP–KYN metabolism and up-regulation of KYN–NAD⁺ metabolism. In summary, results from animal experiments showed that VBPS had a significant anti-anxious depression effects as evidenced by anti-inflammatory, anti-oxidation, reversed behavioral dysfunctions and bodyweight of mice treated with VBPS compared to the anxious depression control mice. It is proved that consume VBPS diets can induce significant beneficial effects on anxious depression.