A low energy consumption drying device based on integration of membrane distillation and liquid desiccant dehumidification was proposed. The basic idea was to transfer the moisture in the material to the liquid desiccant by the dehumidifying-drying unit, and then the moisture absorbed by the liquid desiccant was separated and removed by liquid desiccant regeneration unit. Based on a brief introduction to the structure and principle of the device, an estimation formula for SMER (Specific moisture extraction rate) of the device was given and the SMER of the device can reach 6.36 kg/(kW·h) under typical operating conditions. An experimental device for dehumidifying-drying unit was developed. The heat-sensitive cotton fiber with hydrophilic surface was used as the material to be dried and 50% LiBr aqueous solution was used as the liquid desiccant. And it showed that the moisture in the material was successfully transferred to the liquid desiccant and the experimental device had characteristics such as self-stability and energy self-balance. A liquid desiccant regeneration experimental device based on hollow fiber bundle-sleeve tube air gap membrane distillation module was also developed, and the concentration and regeneration of 50% LiBr aqueous solution was successfully achieved, and the regeneration process had high separation efficiency.