According to the characteristics of non-linear and large time delay in the temperature control system of beer fermentation, proposed the idea of target temperature control combined with fuzzy PID control algorithm, and designed a fuzzy PID controller based on target temperature control point to achieve temperature control, so as to improve the accuracy of temperature control of beer fermentation. Taking Siemens S7-400 PLC and Braumat software platform as the control core, the software and hardware structure of beer fermentation temperature control system was designed to realize the control and monitoring of the whole production process. The field application shows that the temperature control error of beer fermentation is ±0.3 ℃, and the temperature control effect is good, which meets the actual production requirements.