In order to probe the effects of red ginseng extracts irradiated with ⁶⁰Co-γ, the mice model of type I diabetes mellitus was induced by streptozotocin (STZ). The body weight and fasting blood glucose of mice were measured regularly during the experiments. After 30 days’ test, blood samples, which were collected from eyeball and glycosylated hemoglobin (HbAlc), were measured. Total cholesterol (TC) and triglyceride (TG) levels in serum were determined and analyzed. The organs of the heart, liver, spleen and kidney were dissected and the organ coefficients were measured. Results showed that the fasting blood glucose level of mice group feed with high dose of irradiated red ginseng and non-irradiated high dose group was significantly lower than that of the other groups (P＜0.05), but the irradiated group had a lower value than the non-irradiated one. The results of HbAlc and organ coefficient showed that the value of irradiated red ginseng high dose group was closest to that of positive control group, significantly lower than that of the other groups(P＜0.05), and lower than that of non- irradiated high dose group in value. The serum TC, TG were analyzed and the results showed that the irradiated red ginseng high dose group had significant moderating effect on reducing blood lipid concentration in diabetic mice, and is similar to the commercial drugs diabetes-metform in hydrochloride, which can significantly reduce the serum lipid level in diabetes mellitus mice and relief the related complications of diabetes. Therefore, ⁶⁰Co-γ irradiated red ginseng extract can play a role in hypoglycemic.