樟树叶精油抗PM2.5致肺上皮细胞损伤的研究

doi:10.13652/j.issn.1003-5788.2019.09.033

首页 > 过刊浏览>2019年第卷第9期 >169-172. DOI:10.13652/j.issn.1003-5788.2019.09.033

樟树叶精油抗PM2.5致肺上皮细胞损伤的研究
DOI:
                        10.13652/j.issn.1003-5788.2019.09.033
                    
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作者单位:(1. 益阳市产商品质量监督检验研究院，湖南 益阳 413000;2. 中南林业科技大学食品科学与工程学院，湖南 长沙 410004)
作者简介:熊国红，女，益阳市产商品质量监督检验研究院高级工程师，硕士。
通讯作者:付湘晋（1980—），男，中南林业科技大学副教授，博士。E-mail: drxjfu@163.com
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基金项目:国家科技支撑计划（编号：2012BAC01B07-2）；国家林业公益行业科研专项（编号：201104044）

Antagonistic effect of camphor leaf essential oil on damage induced by PM2.5 in lung epithelial cells A549

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(1. Yiyang Institute of Commodity Quality Supervision and Inspection, Yiyang, Hunan 413000, China; 2. College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, Hunan 410004, China)

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摘要:

以肺细胞A549为模型，研究樟树叶精油对PM2.5所致细胞损伤的拮抗活性。研究结果显示：樟树叶精油1.0 mg/mL以内对A549细胞增殖无影响，0.05～1.00 mg/mL 樟树叶精油对PM2.5所致的细胞毒性作用有显著拮抗作用（P＜0.05）；樟树叶精油可显著降低染毒细胞中丙二醛（MDA）含量，增加超氧化物歧化酶（SOD）、过氧化氢酶（CAT）活性和总抗氧化物质（T-AOC）含量（P＜0.05），表明樟树叶精油可通过抗氧化应激拮抗PM2.5致细胞毒性；樟树叶精油可显著降低染毒细胞中炎性因子TNF-α、IL-6的含量（P＜0.05），表明樟树叶精油可通过抑制炎症反应拮抗PM2.5致细胞毒性。

Abstract:

In this paper, the lung cell A549 was used as a model. The protective effect of camphor (C. camphora) leaf essential oil on the A549 exposed to PM2.5 was investigated. Less than 1 mg/mL of essential oil had no effect on A549 cell proliferation, and low concentration had a certain promotion effect. 0.05～1.00 mg/mL essential oil had a significant antagonistic effect on cytotoxicity induced by PM2.5 (P＜0.05). The essential oilsignificantly reduced the content of MDA in the infected cells and increased the activity of SOD and CAT and the content of T-AOC (P＜0.05), indicating that the camphor leaf essential oil could antagonize the cytotoxicity of PM2.5 through antioxidant stress. The camphora leaf essential oilsignificantly reduced the content of TNF-α and IL-6 in the infected cells (P＜0.05), indicating that the camphor leaf essential oil could antagonize the cytotoxicity of PM2.5 by inhibiting the inflammatory reaction.

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熊国红,林海,何建国,等.樟树叶精油抗PM2.5致肺上皮细胞损伤的研究[J].食品与机械,2019,(9):169-172.
XIONGGuohong, LINHai, HEJianguo, et al. Antagonistic effect of camphor leaf essential oil on damage induced by PM2.5 in lung epithelial cells A549[J]. Food & Machinery,2019,(9):169-172.

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收稿日期:2019-06-30
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在线发布日期: 2022-11-24
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