Beer fermentation is an extremely complicated process, in which the control of fermentation temperature has a great influence on the final taste and quality of the beer. The temperature control of the fermentation liquor has the characteristics of large time delay, nonlinear and staged characteristics, and they cause the temperature of the fermented liquor in the fermentation tank to fluctuate frequently with large. According to the technological characteristics of the beer fermentation temperature control system, a nonlinear PID control strategy was processed based on Smith predictable compensation. After modeling the beer fermentation temperature control system and performing Matlab simulation analysis, it was found that the algorithm could retain the advantages of simple PID parameter adjustment and high steady-state accuracy, as well as the greater anti-interference ability. The system was robust to the parameter perturbations and disturbances. The final production results showed that this control strategy could effectively improve the dynamic quality and anti-jamming ability of the control system and obtain better application achievement.