The effects of the polarities of the simulated liquids were investigated on the migration of four antioxidants BHA, BHT, Irganox1076, and Irgafos168 migrated from polypropylene plastics to six different polar simulating solutions. Results, the solubility of antioxidant with polypropylene plastics was worse, the intermiscibility of antioxidant with simulated liquid was better, and the migration equilibrium distribution coefficient was higher. Beyond that, the closer the simulated liquid polarity was to polypropylene, the higher the migration diffusion coefficient was, and the smaller influence of molecular weight on the migration diffusion coefficient of antioxidants was. Conversely, the migration diffusion coefficient would be greatly affected by the molecular weight, and the diffusion coefficient decreased with the increase of the molecular weight. When anhydrous alcohol was used as food simulated liquid, the larger the molecular weight of the antioxidant was, the greater the equilibrium partition coefficient was affected by temperature, and the migration enthalpy increases with the increase of the molecular weight, while the change in n-hexane used as food simulated liquid was exactly the opposite.