A universality recognition to gene and gene modification was mentioned and a concept of “partial gene” etc was proposed according to the practice of gene operations in these years. The opinions and their bases at the two sides of GMF safety argument was screened and teased out entirely. Based on the datum in CNKI and Web of Science, It was discovered that the experimental theses were very few, which can not support this argument at all. Some urgent problems were discussed logically and it has been pointed out that mankind would eat GMF inescapablely while improving and restricting in the future 100-200 years as the big data or a safety impression would being obtained.