In the contemporary social, food packaging design is no longer simply used to protect food and facilitate transportation, but also carries the use of brand image and product marketing promotions. However, when the commerciality of food packaging is overstated, food packaging becomes a commercial tool, triggering a series of food packaging design. The problem of alienation is that food packaging originally serves people, which in turn restricts and affects their own development. Through the analysis of alienation phenomenon in food packaging design, this study intends to warn people to predict the possible consequences of design in time and objectively in food packaging design activities, and remind of the enterprises, designers and consumers to take effective measures actively in order to reduce alienation of food packaging design as far as possible. Finally, a good food package should be designed based on the humankinds and serves us.