Methods The 30 rats were randomly divided into normal control group, the non-treatment group of liver fibrosis model and the treatment group of liver fibrosis model. Each group of rats are take the following operation: Western blotting test OPN protein expression after eitht weeks。The PCR detection of TGF-β1 mRNA expression level. Results This study showed that the treatment group of liver fibrosis model of HA, LN, PCIII, CIV radioimmunoassay were higher than the treatment group have significant differences (P＜0.01), and the differences were statistically significant than the non-treatment group of liver fibrosis model at the same time（P＜0.05）. The non-treatment group of liver fibrosis model of HA(Hyaluronic acid), LN(Laminin), PCIII(Procollagen type III), CIV radioimmunoassay showed significant differences compared to the treatment group of liver fibrosis model （P＜0.01）. Using the treatment group of liver fibrosis model of OPN protein expression level, differences were found inthe normal group（t=2.236, P＜0.05), and the differences were statistically significant than the non-treatment group of liver fibrosis model at the same time (t=1.024, P＜0.01). Using the treatment group of liver fibrosis model of TGF-β1 mRNA expression level of numerical difference compared with normal group (t=2.245, P＜0.05), and compared with the non-treatment group of liver fibrosis model had significant difference (t=1.024, P＜0.01). Conclusions The P. scandens granule could inhibit the OPN protein expression, inhibition of TGF-β1 mRNA expression, slow down the progress of liver fibrosis. Through the experiments, it showed that OPN associated with TGF-β1 regulation of signaling pathway and the specific signaling pathways regulating needs further research.