The occasional communication conflict between PU control system and Wincc in the process of PU control for the beer pasteurization machine were investigated in this study. The sterilization machine automatic PU control system were put forward based on OPC and Wincc. Use the C++ to write OPC client and the Wincc as OPC server to realize the data exchange between Wincc and C++ client. In order to realize the intelligent control of PU, the mathematical model between the PU value of the tunnel sterilizer and the temperature of the nozzle was established, and then the PU control algorithm in the process of beer sterilization was written in high-level language. Moreover, the real-time data transmitted to the PU control software by OPC channel to simulate was used to analyze and calculate the temperature of the spray nozzle to control the temperature of each zone for sterilizer. Finally, the control data was transmitted to the bottom equipment, realizing the real-time automatic control and adjustment of the beer sterilizer. The operation test showed that PU OPC and Wincc beer sterilization machine control system could effectively control and improve the accuracy of sterilization, and increase the beer sterilization process benefit.