With puerarin solid beverage made of pueraria, hawthorn, acid gill, okra, Rhizoma zingiberis, corn peptide and crystalline fructose as the test substance, to study its protection function on chemical hepatic injury by CCl₄ in the Wistar mice. Wistar mice were randomly allocated to negative control group, model control group and three experiment groups, which were treated with intubation of distilled water or 1.08, 2.17 or 4.33 g/kg test substance per day for 30 days. Groups which except negative control group were treated with gastric intubation of CCl₄, and the chemical hepatic injury model was gained. The level of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride (TG) were detected, and then take the liver weight and pathological section for the liver coefficients and observing the pathological changes of liver. Compared with model control group, ALT, AST and liver coefficients were decreased significantly in experiment groups after gastric intubation of CCl₄, also with the mitigatory pathologic changes. And the highest dose experiment group (experiment Ⅲ) gained the most significant effects. Thus, the test substance could protect liver against chemical hepatic injury.